Chronic genitourinary infections involving Corynebacterium pseudogenitalium and Gardnerella vaginalis are uncommon and challenging to identify and treat. Beyond standard antibiotics, a number of lesser-known natural remedies and supplements exhibit antimicrobial effects against these or related bacteria. Many of these agents have broad-spectrum activity (especially against Gram-positive bacteria) and some evidence of systemic distribution or prostate penetration. Below is a structured review of such substances, including their evidence of activity, mechanisms of action (if known), and notes on bioavailability or relevance to prostatic infections.
IMPORTANT NOTE: Diet can severely undermine the treatment/management of this condition. Diets high in refined sugars, processed carbohydrates, and saturated fats can promote the growth and persistence of Gardnerella vaginalis and Corynebacterium pseudogenitalium by disrupting mucosal immunity, raising local pH, and suppressing protective microbiota like Lactobacillus. Furthermore, excess alcohol and iron supplementation may further impair defenses or feed bacterial biofilms, while low fiber and polyphenol intake limits the production of protective metabolites like short-chain fatty acids. These conditions create an internal environment favorable to opportunistic or pathogenic colonization, particularly in the urogenital tract.
In contrast, diets that emphasize anti-inflammatory whole foods, prebiotic fiber, and micronutrient density can help restore microbial balance and strengthen host defenses. Supporting beneficial bacteria through polyphenol-rich foods, fermented foods (if tolerated), and avoiding excess sugars and alcohol are key. Moreover, nutrients like zinc and vitamin D play critical roles in epithelial barrier function and immune modulation. Of course, the objective is not severe restriction but strategic selection: creating an internal terrain that resists colonization and biofilm formation by pathogens, while reinforcing the body’s innate antimicrobial systems.
Garlic (Allium sativum)
Evidence: Garlic has long been used as a natural antimicrobial. Modern studies support its effectiveness against vaginal pathogens. In a clinical trial for bacterial vaginosis (BV), oral garlic tablets showed cure rates comparable to metronidazole (the standard antibiotic) with fewer side effects. This suggests garlic’s components can inhibit G. vaginalis in vivo. In vitro, garlic extracts demonstrate broad antibacterial activity against Gram-positive species (e.g., Staphylococcus and Corynebacterium), indicating potential to affect Corynebacterium pseudogenitalium as well.
Mechanism: The antimicrobial potency of garlic is attributed largely to allicin, a sulfur-containing compound formed when garlic is crushed. Allicin and related thiosulfinates can disrupt bacterial cell walls and enzymes. These compounds are active against both aerobic and anaerobic bacteria. Garlic’s constituents are absorbed upon oral ingestion and partly excreted in urine and prostatic fluid, imparting a garlic odor. This suggests that biologically active metabolites could reach the prostate. Garlic also has immune-stimulating and anti-inflammatory effects that may aid in clearing infections. Overall, oral garlic supplements (in doses used for general health) are a promising natural adjunct for genitourinary infections.
Berberine (Goldenseal Alkaloids)
Evidence: Berberine is a plant alkaloid found in goldenseal (Hydrastis canadensis), barberry, and Argemone mexicana, and it is used traditionally for infections. Berberine exhibits broad antimicrobial activity in vitro, including against BV-related bacteria. Research indicates that berberine can inhibit Gardnerella vaginalis growth and reduce its biofilm formation. In an ethnopharmacology study, Argemone mexicana extracts (rich in berberine) showed significant anti-Gardnerella activity, suppressing planktonic growth and biofilms. Berberine is also reported to interfere with bacterial adhesion in urinary infections. While direct data on C. pseudogenitalium are lacking, berberine’s broad spectrum (covering many Gram-positive rods and anaerobes) makes it a candidate for inhibiting corynebacterial infections.
Mechanism: Berberine disrupts microbes by multiple mechanisms: it can intercalate into DNA, inhibit cell division, and destabilize cell membranes. It also may interfere with quorum sensing and biofilm assembly. In UTIs, berberine prevented uropathogenic bacteria from adhering to bladder cells, which could translate to the prostate environment as well. Bioavailability of oral berberine is moderate – it is not fully absorbed, but significant amounts enter the bloodstream and tissues (berberine often accumulates in organs like the liver and could reach the genitourinary tract). Notably, berberine is yellow and bitter; it’s available in OTC capsules. Although more research is needed, berberine’s broad antimicrobial effect and historical use for urinary tract health suggest it may help suppress G. vaginalis or Corynebacterium infections, especially as part of a herbal regimen.
Cannabidiol (CBD)
Evidence: Cannabidiol (CBD), a non-psychoactive cannabinoid from cannabis, has emerging evidence as an antimicrobial. A recent study showed Gardnerella vaginalis is highly susceptible to CBD, with a very low minimum inhibitory concentration (MIC ~2.5 µg/mL). CBD rapidly reduced G. vaginalis viability, causing ATP leakage and cell death. Importantly, CBD also prevented Gardnerella biofilm formation and even eradicated mature biofilms in vitro. This antibiofilm activity is crucial since G. vaginalis often resides in persistent biofilms. While specific data on C. pseudogenitalium are not published (as far as I know), CBD has known activity against various Gram-positive bacteria, so it may have similar effects on corynebacteria.
Mechanism: CBD’s antimicrobial mechanism appears to involve disruption of the bacterial cell membrane and induction of oxidative stress. In G. vaginalis, CBD caused membrane hyperpolarization and cytoplasmic content leakage. Interestingly, its bactericidal effect was linked to the generation of reactive oxygen species (ROS), as antioxidants could neutralize some of CBD’s activity. CBD is highly lipophilic, which enables it to penetrate tissues and biofilms effectively. When taken systemically (e.g., as oral CBD oil or capsules), it distributes throughout the body and may accumulate in fatty tissues, potentially including the prostate gland (which has a fatty composition). Additionally, CBD is anti-inflammatory. This combination of direct killing, biofilm inhibition, and immune modulation makes CBD a novel candidate for hard-to-treat prostatic infections caused by G. vaginalis or other resistant bacteria. (Note: further clinical research is needed, but initial findings are promising.)
Bee Propolis
Evidence: Propolis is a resinous mixture produced by honeybees from plant resins. It has broad antimicrobial properties and is available as oral supplements or tinctures. Studies have shown propolis to be effective against Corynebacterium species. For example, green and red propolis extracts significantly inhibited C. pseudotuberculosis (a close relative of C. pseudogenitalium) in vitro, even preventing the formation of bacterial biofilms. Propolis was less effective on established, mature biofilms, but it markedly reduced the planktonic growth of the bacteria. Propolis’s activity extends to many Gram-positive bacteria and yeasts; it likely can suppress Corynebacterium pseudogenitalium. Regarding Gardnerella, propolis has traditionally been used for vaginal infections as a topical agent, though formal studies are limited. Its broad antimicrobial spectrum suggests it could inhibit G. vaginalis as well.
Mechanism: Propolis contains dozens of active compounds, including flavonoids (e.g., pinocembrin, galangin), phenolic acids, and aromatic oils. These components exert bactericidal effects by disrupting cell walls, inactivating bacterial enzymes, and blocking cell division. Some flavonoids in propolis intercalate into bacterial membranes and can even inhibit efflux pumps. Because propolis is a complex natural extract, bacteria are less likely to develop resistance to it. When taken orally, propolis compounds are absorbed and widely distributed; some are excreted in urine. Prostate tissue penetration hasn’t been specifically measured, but anecdotal reports and general pharmacology suggest that anti-inflammatory and antimicrobial components of propolis could reach the prostate. In practice, propolis has been used in formulations for chronic prostatitis due to its antibacterial and anti-inflammatory effects. It remains an underutilized natural option for systemic infection control, with a good safety profile (aside from possible allergies in those sensitive to bee products).
Monolaurin (Glycerol Monolaurate)
Evidence: Glycerol monolaurate (GML), also known as monolaurin, is a monoester of lauric acid. It’s derived from coconut oil and is available as a dietary supplement. GML is a potent antimicrobial that has been specifically tested against Gardnerella. In vitro, GML at very low concentrations (10 µg/mL) was bactericidal to G. vaginalis. It also inhibits toxin production in certain bacteria. In a clinical context, a pilot study using intravaginal GML gel for 2 days showed reduced Gardnerella counts in women without harming beneficial Lactobacillus flora. This selective action is valuable because it targets pathogens while sparing normal bacteria. While data on C. pseudogenitalium are not available, GML is known to kill various Gram-positive organisms and could plausibly affect corynebacteria.
Mechanism: Monolaurin works by solubilizing lipid membranes and disrupting the cell envelope of microbes. It can effectively punch holes in the lipid bilayer of bacteria (especially Gram-positive, which have exposed membranes once the cell wall is compromised) and enveloped viruses. GML also has antibiofilm properties and anti-inflammatory effects on mucosal surfaces. Systemically, if taken orally, monolaurin is broken down to lauric acid and glycerol; however, a portion may be absorbed intact or re-formed in tissues, exerting local antimicrobial effects. People use monolaurin for chronic infections due to its safety and broad effects. For prostate relevance, monolaurin’s exact distribution is unclear – it may not concentrate in the prostate directly, but by reducing overall bacterial load (e.g., in gut or urinary tract) and modulating immune response, it could indirectly benefit prostatic infections. Additionally, lauric acid (from which monolaurin is derived) is known to have some presence in prostatic fluid as a natural antimicrobial lipid. Overall, GML is a relatively underrecognized agent that exhibits strong activity against G. vaginalis and possibly other bacteria when used as a supplement.
Lauric Arginate (Lauramide Arginine Ethyl Ester, LAE)
Evidence: LAE is a synthesized derivative of lauric acid and the amino acid arginine (often considered a “natural” preservative used in foods). Though not widely known in medicine, it has shown remarkable efficacy against Gardnerella. In comparative studies, LAE was the most potent agent tested against G. vaginalis biofilms – it had the strongest bactericidal effect, outperforming even the antibiotic clindamycin in reducing viable biofilm cells. LAE effectively killed Gardnerella within established biofilms. There is no direct research on LAE and Corynebacterium pseudogenitalium, but given Corynebacterium’s Gram-positive nature and the broad antibacterial action of LAE, it is likely to have activity there as well.
Mechanism: LAE acts as a cationic surfactant. It integrates into bacterial cell membranes (which are negatively charged) and causes membrane disruption and leakage of cell contents. Essentially, it “dissolves” the protective envelope of bacteria. It may also penetrate biofilm matrices, breaking them apart. Because LAE is amphipathic (having both hydrophilic and lipophilic parts), it can reach bacteria embedded in biofilms – this explains its strong performance against Gardnerella biofilm viability. In terms of bioavailability, LAE is typically used topically or as a food-grade agent; if taken orally as a supplement (not common yet), it would likely be hydrolyzed to lauric acid and arginine. Those metabolites are generally beneficial (lauric acid as described above, arginine for nitric oxide production). It’s unclear if intact LAE can reach the prostate, but its metabolic byproducts can still support antimicrobial defense. While LAE is not yet an over-the-counter supplement in pill form, its impressive anti-Gardnerella effect highlights the potential of fatty acid derivatives in treating biofilm-associated infections.
Subtilosin (Probiotic Peptide)
Evidence: Subtilosin is a bacteriocin – a ribosomally produced peptide antibiotic – secreted by certain probiotic Bacillus strains (e.g., Bacillus subtilis). Though subtilosin is not directly sold as a supplement, it represents a class of natural antimicrobial peptides that could be delivered via probiotic consumption. In lab studies, subtilosin has shown strong activity against G. vaginalis. It was the second most effective natural agent (after LAE) in killing Gardnerella biofilms. Subtilosin significantly reduces Gardnerella viable counts and also inhibits biofilm formation. It has even been tested synergistically: one study found that subtilosin combined with glycerol monolaurate yielded enhanced killing of G. vaginalis. While no direct evidence exists for Corynebacterium pseudogenitalium, many Corynebacterium species are susceptible to cationic peptides, so subtilosin or similar peptides might inhibit them as well.
Mechanism: Subtilosin is a cyclic peptide that can integrate into bacterial cell membranes and form pores, leading to leakage of ions and cell death. It is generally effective against Gram-positive bacteria and some spore-formers. Since it is a protein-based agent, oral delivery would typically digest it; however, a probiotic that produces subtilosin in situ (in the gut or perhaps urinary tract) could deliver it locally. There has been exploration of vaginal suppositories or gels containing subtilosin for BV treatment. For prostate infections, an interesting angle is using probiotics or postbiotic supplements that release bacteriocins into the gut or bloodstream, which might indirectly affect the genitourinary tract. Though currently not available as an isolated OTC oral agent, subtilosin exemplifies how probiotic-derived antimicrobials can target pathogens like G. vaginalis without disrupting beneficial flora. Future supplements or functional foods might harness such peptides to systemically reduce infection.
Thymol (Thyme Oil Component)
Evidence: Thymol is a natural monoterpenoid phenol found in thyme (Thymus vulgaris) and oregano. As an essential oil component, it’s known for its antiseptic properties. Research has demonstrated that thymol can inhibit Gardnerella vaginalis effectively. In an in vitro biofilm model, thymol prevented G. vaginalis from forming biofilms and could even disrupt established biofilms at sub-inhibitory concentrations. A 2010 study showed thymol’s efficacy against both planktonic Gardnerella and its biofilm matrix (with significant inhibition observed even at 1/8th of its MIC). Thymol is also broadly antifungal and antibacterial. Though direct evidence on Corynebacterium pseudogenitalium isn’t published, thymol is active against various Gram-positive bacteria (e.g., Staphylococcus, Enterococcus), so it likely has some effect on corynebacteria as well.
Mechanism: Thymol disrupts the structural integrity of bacterial cell membranes. It is lipophilic and can partition into the lipid bilayer, causing increased permeability and leakage of vital intracellular contents. It may also have an effect on proteins and enzymes in the bacterial cell. When used as an oral supplement (thyme extract or essential oil capsules), thymol can be absorbed, though high doses are needed for systemic levels (it’s rapidly metabolized). Thymol and related terpenes are excreted partly via the lungs and urine, which is why thyme oil has been used traditionally for respiratory and urinary infections. In the context of the prostate, thymol’s strong antimicrobial action could help if delivered to the urinary tract. Some dietary supplements combine thymol-rich oils with other herbs for urinary health. Care must be taken with dosing, as essential oils can be caustic; however, thymol at safe doses could serve as a natural anti-Gardnerella agent, especially in recurrent infections where biofilms are involved.
Carvacrol (Oregano Oil Component)
Evidence: Carvacrol is another phenolic monoterpene, predominantly found in oregano (Origanum vulgare) and thyme. Oregano oil (rich in carvacrol) is a popular natural antimicrobial. Recent research highlights its effectiveness against Gardnerella. A 2022 study showed that carvacrol, especially when combined with certain other terpenes (like p-cymene), had a synergistic lethal effect on Gardnerella spp. in planktonic culture. Carvacrol at sub-MIC levels also significantly eliminated Gardnerella within biofilms, especially when paired with linalool, and did so without harming a model of vaginal epithelial cells. This indicates carvacrol is both potent and relatively safe to host tissues. Oregano oil is known to kill a broad spectrum of bacteria, including multi-resistant strains of staph and others. It’s reasonable to expect Corynebacterium pseudogenitalium would be susceptible as well, though specific data aren’t available.
Mechanism: Carvacrol’s antimicrobial effect, like thymol’s, stems from membrane disruption. It inserts into bacterial membranes and causes structural damage, leading to ion leakage and collapse of the proton motive force. It can also permeabilize the outer membrane of Gram-negatives, making them more susceptible. Additionally, carvacrol has anti-inflammatory and antioxidant properties, which may mitigate tissue damage during infection. Oregano oil (usually standardized to a percentage of carvacrol) is taken orally in gelcaps or liquid drops. It is absorbed and has been detected in the bloodstream after ingestion; some is excreted in urine. Users of oregano oil often report that it can cause a warming sensation, indicative of systemic circulation. For prostate infections, oregano oil could, in theory, deliver carvacrol to the prostate via the bloodstream, given the prostate’s rich blood supply. Indeed, some integrative practitioners use oregano oil for chronic prostatitis as an adjunct therapy. Its strong antibacterial action and ability to work in synergy with other natural compounds make carvacrol a compelling “natural antibiotic” candidate against G. vaginalis biofilms and possibly corynebacterial infections.
Buchu (Agathosma betulina)
Evidence: Buchu is a South African herb traditionally used for urinary tract ailments. The leaves of buchu contain a variety of essential oils and flavonoids. Buchu is a lesser-known remedy, but studies confirm it has broad antimicrobial effects in the urinary tract. Ethanolic extracts of A. betulina leaves have shown activity against common UTI pathogens, including E. coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus saprophyticus, Staph. aureus, and Enterococcus faecalis. This spectrum covers both Gram-negative and Gram-positive bacteria. While G. vaginalis and Corynebacterium were not specifically tested, the fact that buchu inhibited all these diverse bacteria suggests a general antiseptic property that could extend to less common urogenital microbes. Buchu has been used historically for prostatitis as well, implying anecdotal efficacy.
Mechanism: Buchu’s main active constituents are volatile terpenoids in its oil. Notably, terpinen-4-ol (also found in tea tree oil) is a major component and is believed to contribute strongly to buchu’s antibacterial action. Terpinen-4-ol has antiseptic and anti-inflammatory properties. In buchu, this and other compounds likely work by disrupting bacterial membranes and perhaps by diuretic action (flushing out the urinary tract). Buchu leaf also has mild diuretic effects, increasing urine flow, which can help clear bacteria. After oral intake (often as buchu tea or capsules), the essential oil components are excreted into the urine, where they exert a topical antimicrobial effect along the urinary tract lining. This means buchu’s active compounds likely reach the bladder and possibly the prostate via diffusion from prostatic fluid into the urethra. Additionally, buchu’s anti-inflammatory nature can soothe urinary tract irritation. In summary, buchu is a relatively underutilized herb that acts as a urinary disinfectant and anti-inflammatory; its broad antibacterial range suggests it could help control G. vaginalis or Corynebacterium if they are present in the prostate or urethra.
Uva Ursi (Arctostaphylos uva-ursi, Bearberry)
Evidence: Uva ursi is a well-known traditional remedy for UTIs, though not widely used in mainstream practice today. Its efficacy comes from the compound arbutin (a glycoside) in the leaves. Arbutin is converted to hydroquinone in the body, which is a powerful antimicrobial. Studies have demonstrated that arbutin and its metabolites can destroy both Gram-negative and Gram-positive bacteria, as well as some fungi. Pathogens inhibited by arbutin include Pseudomonas aeruginosa, Staph. aureus (including MRSA), and Enterococcus – indicating a broad antimicrobial range. Uva ursi’s hydroquinone release in urine creates an antiseptic environment in the lower urinary tract. Clinically, Uva Ursi (often given as a tincture or capsule) has been reported to reduce symptoms of mild UTIs, and it’s considered a “urinary antiseptic” in herbal medicine. There are no direct studies on G. vaginalis or Corynebacterium with uva ursi, but Gardnerella (being a Gram-variable bacterium) and Corynebacterium (Gram-positive) would likely be susceptible to hydroquinone’s disinfectant action.
Mechanism: Arbutin itself is not very antimicrobial until it is hydrolyzed. After oral ingestion, gut bacteria and the liver enzymatically cleave arbutin to hydroquinone, which is then conjugated and excreted in the urine. In the urinary tract (bladder, prostate, urethra), the conjugated hydroquinone can revert to free hydroquinone, which acts as an antiseptic – it denatures bacterial proteins and damages bacterial cell walls. This mechanism specifically targets the urinary system, making Uva Ursi particularly effective for lower UTIs. For prostate infections, hydroquinone can diffuse from urine into prostatic ducts or reach the prostate via circulation, providing localized antimicrobial effects. Uva ursi also contains tannins that have astringent (tissue-tightening) and anti-inflammatory effects on the urinary mucosa. Bioavailability: The key is that sufficient arbutin is taken so that active hydroquinone levels in urine reach bactericidal range. Uva ursi supplements standardized to arbutin ensure this; typically, a course is not used long-term (due to concerns of hydroquinone toxicity with extended use), but short-term use is considered safe. In sum, Uva Ursi serves as a plant-derived urinary tract antiseptic, capable of killing bacteria in situ, which could help eradicate lingering G. vaginalis or Corynebacterium in the prostate/urethra when used appropriately.
Zinc Supplements
Evidence: Zinc is an essential mineral, and interestingly, it is nature’s own antimicrobial agent in the prostate. Healthy prostatic fluid contains very high levels of zinc, which contributes to its antibacterial activity. Men with chronic prostatitis or recurrent prostate infections often have lower prostatic zinc levels than normal. While zinc itself is not typically considered an “antibiotic,” it has been shown to inhibit the growth of various pathogens. Historical research identified a “prostatic antibacterial factor” in semen, which was later found to be largely due to zinc ions. Thus, maintaining adequate zinc might be crucial for innate defense against Corynebacterium or Gardnerella in the prostate. Some small studies and much anecdotal evidence suggest zinc supplementation can help reduce prostate inflammation and infection risk. For example, zinc in prostatic fluid can directly inhibit E. coli and other uropathogens; it’s reasonable to extrapolate a similar effect on G. vaginalis or Corynebacterium pseudogenitalium, especially since these are not highly virulent bacteria.
Mechanism: Zinc ions have a direct antimicrobial effect by multiple pathways. They can damage bacterial membranes, produce oxidative stress, and interfere with nutrient uptake and enzyme function in microbes. In viruses, zinc can inhibit replication; in bacteria, high local zinc concentrations are toxic. Within the prostate, zinc is concentrated by prostate epithelial cells and secreted into prostatic fluid. This creates a hostile environment for bacteria in the ejaculatory ducts and urethra. Oral zinc supplements (such as zinc citrate or zinc gluconate) can raise serum and prostatic fluid zinc levels when taken over time. Zinc also supports immune function, aiding in the overall clearance of infections. Importantly, zinc’s activity is “natural” to the body – supplementing aims to restore physiological levels. For instance, one study noted that zinc may serve as an in vivo defense against prostatic infection and that this factor is diminished in prostatitis. Therefore, ensuring adequate zinc intake (through diet or supplements) is a sensible strategy to enhance the prostate’s antimicrobial defenses. Doses in the range of 30–50 mg daily are often used for prostate health (with medical supervision to avoid excessive intake).
NOTE: Zinc should ALWAYS be taken in combination with copper.
N-Acetylcysteine (NAC)
Evidence: NAC is a supplement known mostly as a mucolytic and antioxidant, but it also has notable antimicrobial adjunct properties. It does not directly kill bacteria at typical concentrations, but NAC is very effective at disrupting biofilms and preventing bacterial adhesion. In urinary tract models, NAC reduced the ability of bacteria to stick to bladder wall cells. It can also inhibit biofilm formation by a variety of pathogens (from E. coli to Pseudomonas to Gram-positives). For catheter-associated UTIs, NAC was shown to prevent encrustation and block urease activity of Proteus, leading to 4–8 log reductions in bacterial counts on catheters. These findings illustrate NAC’s power in preventing chronic, embedded infections. In the context of G. vaginalis or Corynebacterium, which may form biofilms in the prostate or urinary tract, NAC could help break up these biofilms and expose bacteria to the immune system or other antimicrobials.
Mechanism: NAC primarily works by supplying cysteine to boost glutathione levels (antioxidant effect) and by cleaving disulfide bonds in mucus and biofilm matrices. Bacterial biofilms often contain extracellular polymers (including DNA and proteins) that are stabilized by disulfide bonds; NAC can reduce (break) these bonds, thereby destabilizing the biofilm structure. It can also chelate metals and alter the production of extracellular polysaccharides. Additionally, NAC’s antioxidant property may reduce the inflammatory damage in tissues, promoting healing. Regarding pharmacokinetics, NAC is well absorbed orally and distributes widely; it is known to reach respiratory secretions and likely reaches prostatic fluid as well (some physicians use NAC in chronic prostatitis protocols for this reason). NAC is safe and over-the-counter, typically given at 600–1200 mg two or three times daily for biofilm-related conditions. By making biofilm-encased bacteria more vulnerable, NAC can indirectly lead to their eradication. For a prostate infection, combining NAC with a targeted antimicrobial (whether natural or pharmaceutical) might significantly improve outcomes.
Serratiopeptidase (Serrapeptase)
Evidence: Serrapeptase is a proteolytic enzyme originally from silkworms, now used as a supplement for its anti-inflammatory and biofilm-busting benefits. It has no direct “antibiotic” activity in the traditional sense, but it has been classified as a biofilm buster in medical literature. Serrapeptase can impair the formation of bacterial biofilms and even help dissolve existing biofilm matrices. Over 80% of chronic infections involve biofilms, and serrapeptase has shown efficacy in reducing these, thereby exposing bacteria to immune attack or antibiotics. Studies demonstrate that serrapeptase inhibits biofilm formation by Staph (both MRSA and MSSA) and other bacteria. When used in combination with antibiotics, serrapeptase greatly enhanced their penetration and effectiveness against resistant bacteria. In a chronic prostatitis context, many patients report relief when adding serrapeptase to their regimen, likely because it helps break down fibrotic tissue and biofilm shielding the bacteria (as also evidenced by some small trials in ENT and orthopedic infections).
Mechanism: Serratiopeptidase is a protease enzyme that degrades proteins, specifically, it can break down components of biofilms (such as extracellular DNA/protein scaffolding) and devitalize non-living tissue. Cleaving these materials removes the “shield” that bacteria produce. Serrapeptase doesn’t kill bacteria outright, but it strips their protection, allowing immune cells or antibiotics to eliminate the pathogens. It also reduces the viscosity of fluids and can improve microcirculation at infection sites. Moreover, serrapeptase is strongly anti-inflammatory: it helps degrade inflammatory mediators and has been shown to reduce swelling and pain in various conditions. In terms of distribution, serrapeptase is orally bioavailable when enteric-coated (to survive the stomach). It has been found to reach sites of inflammation; physicians in Europe and Asia have used it for decades for inflammation in joints, sinuses, and postoperative sites. For the prostate, an inflamed gland with possible fibrous deposits can potentially be penetrated by serrapeptase, which may dissolve the excess fibrin and improve antibiotic access. While formal studies in prostatitis are scarce, the enzyme’s known actions support its use as an adjunct to “clear the way” for other antimicrobial agents to work. Serrapeptase is typically taken on an empty stomach (to avoid protein in food deactivating it), at dosages like 20,000 – 250,000 units. It should be used with medical guidance, especially if on blood thinners (as it can enhance fibrinolysis).
The Combination Strategy
Each of these agents offers a unique approach to inhibiting or destroying the target bacteria. For a prostate infection scenario, a combined strategy might be most effective – for example, using a direct antimicrobial (like garlic or berberine) along with a biofilm disruptor (NAC or serrapeptase) and immune-supportive nutrients (zinc/copper). In long-standing chronic cases, changing strategies every two months might be helpful.
A Great Starting Treatment Stack w/ Duration
| Component | Duration (Suggested) |
|---|---|
| Garlic Extract (Allicin standardized) 600–1200 mg/day | 60 days |
| Berberine HCL 500 mg, 2x daily with meals | 60 days |
| N-Acetylcysteine (NAC) 600 mg, 2–3x daily between meals | 60+ days |
| Serrapeptase 40,000–120,000 SPU/day (empty stomach) | 60 days |
| Zinc (with Cu) 30–50 mg/day with meals | Ongoing |
| CBD/Cannabidiol (Full Spectrum or Isolate) 25–50 mg/day with meals | 60 days |
| Uva Ursi 500 mg, 2x/day between meals | 5–7 day cycles (PRN) |
A Special Note on Berberine and NAC: Although both berberine and N-acetylcysteine (NAC) offer antimicrobial and anti-biofilm benefits, they may partially counteract each other when used together. Berberine exerts some of its antimicrobial effects through the generation of reactive oxygen species (ROS), while NAC is a potent antioxidant that neutralizes ROS. This means that NAC could potentially reduce berberine’s ROS-dependent microbial killing capacity. However, berberine also works through other mechanisms—such as inhibiting DNA replication and disrupting bacterial membranes—which are unaffected by NAC. To maximize their complementary benefits, it is advisable to separate their dosing by a few hours, allowing each to act optimally without significant interference.
It’s also important to note that while these natural options have shown activity against G. vaginalis, Corynebacterium, or analogous microbes, clinical evidence in prostatitis specifically is severely limited. Nonetheless, their low toxicity and multi-faceted benefits make them attractive adjuncts. Integrating such remedies under professional guidance could improve outcomes in stubborn prostatic infections, especially when conventional antibiotics alone are insufficient or undesired.
Dr. Robertson is a health researcher and educator, not a physician. The information provided here is not medical advice, a professional diagnosis, opinion, treatment, or service to you or any other individual. The information provided is for educational and anecdotal purposes only and is not a substitute for medical or professional care. You should not use the information in place of a visit, call, consultation, or the advice of your physician or other healthcare providers. Dr. Robertson is not liable or responsible for any advice, course of treatment, diagnosis, or additional information, services, or products you obtain or utilize. IF YOU BELIEVE YOU HAVE A MEDICAL EMERGENCY, YOU SHOULD IMMEDIATELY CALL 911 OR YOUR PHYSICIAN.
Resources and Reading
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Health Benefits of Serrapeptase – https://www.webmd.com/diet/health-benefits-serrapeptase
Review article: The significance of arbutin and its derivatives in therapy and cosmetics – https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/arbutin#:~:text=Arbutin%20,astringent%2C%20disinfectant%20and%20antioxidant